Challenging the dogma (1): progressive MS and remyelination

In response to a comment concerning dogma in the field of MS, I am going to publish a series of posts that are designed to "challenge the dogma". 


Dogma: persistent demyelination is a pathological features of non-relapsing progressive MS, i.e. secondary and primary progressive MS. 






Question for Dr K: What is the evidence that there a sufficient number of demyelinated axons in non-relapsing progressive MS for remyelination therapeutic strategies to work?  


dog·ma (dôgm, dg-)

n. pl. dog·mas or dog·ma·ta (-m-t)
An authoritative principle, belief, or statement of ideas or opinion, especially one considered to be absolutely true.