I would be interested to know if the pwMS. who had died in this post-mortem series, had signed an advanced directive before ending-up in ITU? An advanced directive needs to be done at a stage of your life when you are of sufficient mind to instruct your doctors and family how you want to be managed when critically ill. I know from a survey we did at Barts-MS several years ago that the majority of pwMS who were in the late, or terminal, stages of their disease and didn't want intensive therapy. If you haven't done so already I would urge you to discuss signing an advanced directive with your family and HCPs and then to complete one. There is good evidence that advanced directives are a very cost-effective tool in improving quality of life and saving you and society unnecessary and sometime futile healthcare expenses. Advanced directives also make things a lot easier for your family; they remove the stress of complex decision-making at the end-of-life.
Karamyan et al. Causes of death in critically ill multiple sclerosis patients Acta Neurologica …, 2016
Background: Patients with multiple sclerosis (MS) experience higher mortality rates as compared to the general population. While the risk of intensive care unit (ICU) admission is also reported to be higher, little is known about causes of death CoD in critically ill MS patients.
Aim: To study the causes of death (CoD) in the series of critically ill patients with MS verified by autopsy.
Methods: We reviewed hospital electronic charts of MS patients treated at the neurological ICU of a tertiary care hospital between 2000 and 2015. We compared clinical and pathological CoD for those who were autopsied.
Results: Overall, 10 patients were identified (seven female; median age at death 65 years, range 27-80), and six of them were autopsied. The median MS duration prior to ICU admission was 27.5 years (range 1-50), and the median EDSS score at the time of ICU admission was 9 (range 5-9.5). The median length of ICU stay was 3 days (range 2-213). All the individuals in our series had experienced respiratory insufficiency during their ICU stay. The autopsy examination of brain tissue did not reveal evidences of MS lesions in one patient. In another patient, Lewy bodies were found on brain immunohistochemistry.
Conclusion: Mortality in critically ill MS patients is largely driven by respiratory complications. Sporadic disparities between clinical and pathological findings can be expected.